25 Oct. 2018 Large-scale cancer study locates “light switches” in the “dark” regions of the genome

5 April 2018 Van Andel Research Institute scientists help redefine how cancer is categorized: Comprehensive scientific resource highlighted in more than two dozen papers published in Cell Press by The Cancer Genome Atlas

5 April 2018 Comprehensive atlas redefines gastrointestinal cancers
VAI Voice

2 April 2018 Scientists discover new method for measuring cellular age: Nature Genetics paper shows cells begin losing important DNA marks in utero

21 June 2017 Research brief: Developing a “roadmap” for the second deadliest cancer worldwide
VAI Voice

14 March 2017 Four molecular subtypes revealed in rare bile duct cancer
VAI Voice

4 Jan. 2017 Comprehensive study of esophageal cancer reveals several molecular subtypes, provides new insight into increasingly prevalent disease

17 Nov. 2016 Van Andel Research Institute, Cedars-Sinai awarded National Cancer Institute grant for epigenomic data analysis

6 Sept. 2016 Peter Laird: Epigenetics, DNA methylation and Arrays (Illumina)

5 Nov. 2015 TCGA findings provide molecular background for second most common kidney cancer

2 Sept. 2014 Van Andel Research Institute names new assistant professor as part of epigenetics expansion

Zhou W et al. DNA methylation loss in late-replicating domains is linked to mitotic cell division. Nat Gen

The Cancer Genome Atlas Research Network Group. Comprehensive molecular characterization of papillary renal cell carcinoma. New Eng J Med

Kim H et al. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res

Yao L et al. Inferring regulatory element landscapes and transcription factor networks from cancer methylomes. Genome Biol

Kim SE et al. γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. Genes Nutr

Weisenberger DJ et al. Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history. Cancer Epidemiol Biomarkers Prev

The Cancer Genome Atlas Research Network Group. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature

The Laird Laboratory focuses on the role of epigenetics in cancer, combining mechanistic studies in model systems, analysis of human cancer tissues, advanced technology development, and epigenomic data analysis. They seek to hire for the following positions:

• Postdoctoral fellow: A major focus of this position will be to investigate cellular epigenetic heterogeneity as a predeterminant of malignant transformation potential using single cell epigenomics in mouse and human model systems. This position will include an element of technology development and epigenomic data analysis. Learn more and apply here.
• Research technician: Responsibilities include maintenance of cell lines, animal colony maintenance, molecular cloning, biochemistry, flow cytometry and general laboratory work. Learn more and apply here.